Paper & Patents

Pyruvate kinase M2 Accelerates Cutaneous Wound Healing via Glycolysis and Wnt/β-Catenin Signaling

KY19382 Accelerates Cutaneous Wound Healing via Activation of the Wnt/β-Catenin Signaling Pathway

Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair

Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/β-catenin signaling pathway

Recent Updates on Development of Wnt/β-catenin Pathway Activators for Alopecia Treatment

Structural optimization of novel Ras modulator for treatment of Colorectal cancer by promoting β-catenin and Ras degradation

Adhesive hydrogel patch-mediated combination drug therapy induces regenerative wound healing through reconstruction of regenerative microenvironment

Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation

CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2

Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-catenin Signaling

Blockade of CXXC5-dishevelled interaction inhibits adipogenic differentiation, obesity, and insulin resistance in mice

Euodia daniellii Hemsl. Extract and Its Active Component Hesperidin Accelerate Cutaneous Wound Healing via Activation of Wnt/β-catenin signaling Pathway

Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment

Seol Hwa Seo, Eunhwan Kim, Minguen Yoon, Soung-Hoon Lee, Byung-Hyun Park and Kang-Yell Choi

Experimental and Molecular Medicine 2022 https://doi.org/10.1038/s12276-022-00851-8

Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopeica Treatment

Youseong Kim, Yeong Chan Ryu, Hye Su Min, Huisuk Yang, Jeehye Nam, Chisong Lee, Daniel Junmin Um, Miji Kim, Paola Atzei, Rita de Brito Francisco, Reto Naef,  Kang-Yell Choi, Hyungil Jung

Advanced Therapeutics 2022 DOI: 10.1002/adtp.202200052

Indirubin-3'-alkoxime derivatives for upregulation of Wnt signaling through dual inhibition of GSK-3β and the CXXC5-Dvl interaction

Doona Song, Yunja Lee, Min-Jeong Kang, Jae Won Kim, Soung-Hoon Lee, Kang-Yell Choi, Eun-Yeong Kim, Kiho Lee, Gyoonhee Han

Bioorganic Chemistry 2022 DOI: 10.1016/j.bioorg.2022.105664

Inhibition of CXXC5 function reverses obesity-related metabolic diseases

Seo, SH, Kim, EH, Lee, SH, Lee, YH, Han, DH, Go, H, Seong, JK, and Choi, KY.
Clinical and Translational Medicine 2022 12(4); e742

Differences in Proportion of N-acetyllactosamine and O-acetylated Sialic Acid Have No Significant Effect on the Pharmacokinetics and Biological Activity of Darbepoetin Alfa

Won Jeong Lee, Hookeun Oh, Inseong Choi, Keunho Lee, Hyunwoo Shin, Yoon Jung Lee, Jeehye Park, Yoo Hee Yang, Gyong-Sik Ha, Dong-Eok Lee, Kang-Yell Choi, and Eunyoung Choi 

Biotechnology and Bioprocess Engineering 2022 DOI 10.1007/s12257-021-0042-0

Approaches for regenerative healing of cutaneous wound with an emphasis on strategies activating the Wnt/β-catenin pathway

Sehee Choi, Minguen Yoon, Kang-Yell Choi

Advances in Wound Care 2022 DOI:10.1089/wound.2022.1284

Suppression of Wnt/b-catenin and RAS/ERK pathways provides a therapeutic strategy for gemcitabine-resistant pancreatic cancer
Won-Ji Ryu, Gyoonhee Han, Soung-Hoon Lee, Kang-Yell Choi
Biochemical and Biophysical Research Communications 2021 https://doi.org/10.1016/j.bbrc.2021.02.076:

PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury

Won Chan Hwang, Seol Hwa Seo, Minju Kang, Rae Hee Kang, Gilbert Di Paolo, Kang‐Yell Choi, Do Sik Min

J Cell Physiol 2021 DOI: 10.1002/jcp.30224:

KY19382, a novel activator of Wnt/β-catenin signaling, promotes hair re-growth and hair follicle neogenesis

Yeong Chan Ryu, Dong-Hwan Lee, Jiyong Shim, Jiyeon Park, You-rin Kim, Sehee Choi, Soon Sun Bak, Young Kwan Sung, Soung-Hoon Lee, and Kang-Yell Choi
British Journal of Pharmacology 2021 DOI: 10.1111/bph.15438

Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis
Dong Woo Kang, Won Chan Hwang, Yu Na Noh, Xiangguo Che, Soung-Hoon Lee, Younghoon Jang, Kang-Yell Choi, Je-Yong Choi, Do Sik Min
BBA - Molecular Basis of Disease 2021 https://doi.org/10.1016/j.bbadis.2021.166084:

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Dong-Kyu Kwak, Jaebeom Cho, Dong Woo Kang, Ho-Young Lee and Kang-Yell Choi.

BMC Cell Communication and Signaling 2020 https://doi.org/10.1186/s12964-020-0519-z:

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer
Won-Ji Ryu, Jeong Dong Lee, Jong-Chan Park, Pu-Hyeon Cha, Yong-Hee Cho, Jee Ye Kim, Joo Hyuk Sohn, Soonmyung Paik and Kang-Yell Choi.

Experimental Molecular Medicine 2020 https://doi.org/10.1038/s12276-020-0440-y:

APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer

Pu-Hyeon Cha, Jeong-Ha Hwang, Dong-Kyu Kwak, Eunjin Koh, Kyung-Sup Kim and Kang-Yell Choi.
British Journal of Cancer 2020 https://doi.org/10.1038/s41416-020-01118-7:

A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling
Hwang, JH, Yoon, JY, Cho, YH, CBha, PH, Park, JC, and Choi KY.
International Journal of Cancer. 2020 doi: 10.1002/ijc.32728:

A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog
Seol Hwa Seo, Eunhwan Kim, Yechan Joo, Juseung Lee, Kyung Taek Oh, Sung-Joo Hwang and Kang-Yell Choi.
MDPI pharmaceutics 2020 Pharmaceutics 2020,12,175; doi:10.3390/pharmaceutics12020175:

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Tomohiro Mizutani, Dong-Woo Kang, Jong-Chan Park, Tae Il Kim, Hans Clevers and Kang-Yell Choi.
Nature communications 2020 https://doi.org/10.1038/s41467-020-19173-2:

WDR76 mediates obesity and hepatic steatosis via HRas destabilization

Park, JC, Jeong, W-J, Seo, SW, and Choi KY.

Scientific Reports 2019 9(1):19676. doi: 10.1038/s41598-019-56211-6.:

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Jeong, WJ, Park, JC, Kim, WS, Ro, EJ, Jeon, SH, Lee, SK, Park YN, Min, DS, and Choi KY.

Nature Communications 2019 10(1):295. doi: 10.1038/s41467-018-08230-6.:

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

Ro, EJ, Cho, YH, Jeong, WJ, Park, JC, Min, DS, Choi KY.

Cell Communication and Signaling. 2019 17(1):88.:

Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway

Choi S, Cha PH, Kim HY, Choi KY.

Exp Mol Med. 2019 12;51(9):104. doi: 10.1038/s12276-019-0306-3.:

CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

Choi, SE, Kim, HY, Cha, PH, Seo, SH, Lee C, Choi, Y, Shin W, Heo, Y, Han GH, Lee WT. and Choi KY.

Life Science Alliance 2019 10;2(2). pii: e201800254.:

A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both β-Catenin and RAS.

Ryu WJ, Lee JE, Cho YH, Lee G, Seo MK, Lee SK, Hwang JH, Min DS, Noh SH, Paik S, Kim S, Cheong JH, Choi KY.
Cancers (Basel) 2019 8;11(4). pii: E496.:

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer.

Park, J., Cho, YH., Shin, WJ., Lee, J., Lee, SK., Kim, TH., Cha, PH., Yang, JS., Cho, JB., Min, DS., Han, G., Lee, HY., Choi KY.
Scientific Reports 2019 648. doi: 0.1038/s41598-018-37059-8:

β-Catenin-RAS interaction serves as molecular switch for RAS degradation via GSK3β.

Lee, SK, Jeong, WJ, Cho, YH, Cha, PH, Yoon JS, Ro EJ, Choi SH, Oh, JM, Heo,YS, Kim H, Min, DS, Han, G, Lee, W, Choi KY.
EMBO Reports 2018 pii: e46060:

Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth.

Lahiji, SF. Seo, SH., Kim, S., Dangol, M., Shim, J., Li, CG., Ma, Y., Lee, C., Kang, G., Yang, H., Choi KY., Jung H.
Biomaterials. 2018 160:69-79

Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis.

Lee, SK., Hwang, JH., Choi KY.
Advances in Biological regulation. 2018 Jan 10. pii: S2212-4926(18)30002-2:

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway.

Jeong WJ, Ro EJ, Choi KY.
npj Precision Oncology. 2018 2, article number 5:

Identification of Ras degrading small molecules inhibiting the transformation of colorectal cancer cells independently of β-catenin signaling.

Shin, W., Lee, SK., Hwang, JH, Park JC, Choi, YH, Ro EJ, Song Y, Seo HR., and Choi KY.
Experimental Molecular Medicine. 2018 50:71

Discovery of A Small-Molecule Inhibitor of Dvl CXXC5 Interaction by Computational Approaches.

Ma, S, Choi, J, Jin, X, Kim, HY, Yun, JH, Lee, W, Choi KY, No, KT.
Journal of Computer-Aided Molecular Design. 2018 32:643-655

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab.

Lee, SK, Choi YH, Cha, PH, Yoon JS, Ro, EJ, Jeong WJ, Park, JE, Kim, H, Kim TI, Min DS, Han G, and Choi KY.
Experimental Molecular Medicine. 2018 50(11):153

Targeting of CXXC5 by a competing peptide stimulates hair re-growth and wound-induced hair neogenesis.

Lee, SH, Seo, SH, Lee DH, Pi, L-Q, Lee, WS, and Choi KY
Journal of Investigative Dermatology. 2017 137:2260-2269

Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells.

Lee KH, Jeong, WJ, Cha, PH, Lee, SK, Min DS, Choi KY.
Oncotarget. 2017 8:115596-115608

Screening-based approaches to identify small molecules that inhibit protein-protein interactions.

Choi S, Choi KY
Expert Opin Drug Discov 2017 12:293-303

Phospholipase D1 inhibition linked to upregulation of ICAT blocks colorectal cancer growth hyperactivated by Wnt/β-catenin and PI3K/Akt Signaling.

Kang, DW, Lee, BH, Suh, Y-A, Choi, Y-S. Jang, SJ, Kim, Y-M, Choi KY., Min DS.
Clinical Cancer Res. 2017 (Epub ahead of print)

Phospholipase D1 acts through Akt/TopB1 and RB1 to regulate the E2F1-dependent apoptotic program in cancer cells.

Kang, DW., Lee, SW, Hwang, WC, Lee, BH, Choi, YS, Suh, YA, Choi KY., Min, DS.
Cancer Research. 2017 77(1): 142-52

MicroRNA-320a and microRNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A (CagA)-induced cancer-initiating potential and chemoresistance by targeting β-catenin and ATP-binding cassette, subfamily G, member 2.

Kang DW, Yang ES, Noh YN, Hwang WC, Jo SY, Suh YA, Park WS, Choi KY, Min DS.
J Pathol. 2017 241:614-625

Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5.

Lee I, Choi S, Yun JH, Seo S, Choi S, Choi KY, Lee W.
Biochem Biophys Res Commun. 2017 485:584-590

CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation.

Kim MY, Kim HY, Hong J, Kim D, Lee H, Cheong, E, Lee, Yangsin, Roth J, Kim, DG, Min DS, Choi KY.
Glia 2016 64(3):350-362

Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing.

Seo SH, Lee SH, Cha PH, Kim MY, Min DS, Choi KY.
Phytotherapy Research 2016 

Small molecule inhibitors of Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy.

Kim HY, Choi S, Yoon JH, Lim HJ, Lee H, Choi J, Neo JN, Lee W, No KT, Choi KY.
EMBO Molecular Medicine 2016 

Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation.

Cha PH, Cho YH, Lee SK, Lee JH, Jeong W-J, Moon B-S, Yun JH, Yang JS, Choi SH, Yoon JY, Kim HY, Kim, MY, Kaduwal S, Lee W, Min DS, Kim Hg, Han GH, and Choi KY.
Nature Chemical Biology. 2016 12(8):593-600

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer.

Cho YH, Cha P, Kaduwal S, Park JC, Lee SK, Yoon JS, Shin W., Kim H, Ro EJ, Koo KH, Park KS, Han GH, and Choi KY.
Oncotarget. 2016 7(49):81727-81740

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing.

Lee SH, Kim MY, Kim HY, Lee YM, Kim H, Nam KA, Roh MR, Chung KY, Choi KY.
Journal of Experimental Medicine 2015 212(7):1061-1080 

K-Ras stabilization by estrogen via PKCd is involved in endometrial tumorigenesis.
Koo KH, Jeong WJ, Choi YH, Park JC, Min DS, Choi KY.
Oncotarget 2015 6(25):21328-21340 IF =6.63

CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation.
Kim HY, Yoon JY, Yoon JH, Cho KW, Lee SH, Rhee YM, Jung HS, Lim HJ, Choi JW, Heo JN, Lee WT, No KT, Min DS, Choi KY.
Cell Death and Differentiation 2015 22:912-920 IF =8.385

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling.
Kaduwal S, Jeong WJ, Park JC, Lee KH, Lee YM, Jeon SH, Lim YB, Min DS, Choi KY.
Oncotarget 2015 6(32):33091-33105 IF =6.359

Targeting phospholipaseD1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells.
Kang DW, Choi CY, Cho YH, Tian H, Di Paolo G, Choi KY, Min DS.
Journal of Experimental Medicine 2015 212:1219-1237 IF =13.912

Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/beta-catenin pathway activation.
Hwang JH, Cha PH, Han G, Bach TT, Min DS, Choi KY.
Experimental and Molecular Medicine 2015 47:e152 IF =2.462

NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1.
Kim KH, Kim DY, Park JY, Jung HJ, Cho YH, Kim HK, Han J, Choi KY, Kwon HJ.
J. Mol. Medicine 2015 93:5 IF =4.739

N-nicotinoyl tyramine, a novel niacinamide derivative, inhibits melanogenesis by suppressing MITF gene expression.
Kim B, Lee SH, Choi KY, Kim HS.
European Journal of Pharmacology 2015 764:1-8 IF =2.532

CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation.
Kim HY, Yang DH, Shin SW, Kim MY, Yoon JH, Kim S, Park HC, Kang DW, Min DS, Hur MW, Choi KY.
FASEB J 2014 28:615-626 IF =5.704

Indirubin-3'-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice.
Zahoor M, Cha PH, Choi KY.
Bone 2014 65:60-68 IF =4.461

Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells.
Hwang WC, Kim MK, Song JH, Choi KY, Min DS.
Experimental and Molecular and Medicine 2014 46:e124 IF =2.462

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1alpha stability.
Park MH, Choi KY, Jung Y, and Min DS.
Oncotarget 2014 5:11857-11872 IF =6.627

Selected as a featured article on MDLinx on 9th of August
Strategies to overcome resistance to EGFR monoclonal antibody therapy in metastatic colorectal cancers.
Jeong WJ, Cha PH, Choi KY.
World Journal of Gastroenterology 2014 20:9862-9871 IF =2.433

Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy.
Jang YH, Choi KY, Min DS.
Cell Death and Differentiation 2014 21:533-546 IF =8.358

Functional Regulation of Phospholipase D Expression in Cancer and Inflammation.
Kang DW, Choi KY, Min DS.
J. Biol. Chem. 2014 289:22575-22582 IF =4.600

The small molecule indirubin-3´-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
Choi OM, Cho YH, Choi S, Lee SH, Seo SH, Kim HY, Han G, Min DS, Park T, Choi KY.
International Journal of Obesity 2014 38:1044-1052 IF =5.386

Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice.
Cha PH, Shin W, Zahoor M, Kim HY, Min DS, Choi KY.
PLOS ONE 2014 22:e85546 IF =3.3.534

Indirubin-3’-oxime Reverses Bone Loss in Ovariectomized and Hindlimb-Unloaded Mice via Activation of the Wnt/β-Catenin Signaling.
Zahoor, M, Cha PH, Min DS, Choi KY.
Journal of Bone and Mineral Research 2014 29:1196-1205 IF =6.589

Editorial Reviewed by Eric Feron
The Role of Oncogenic K-Ras Accelerates Cancer Stem Cell Activation via Aberrant Wnt/β-catenin Signaling.
Moon BS, Jeong WJ, Park J, Kim TI, Min DS, Choi KY.
Journal of the National Cancer Institute 2014 106:1-10 IF =15.161

Response to Cristobal.
Moon BS, Cho YH, Jeong WJ, Choi KY.
Journal of the National Cancer Institute 2014 8:1 IF =15.161

Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents.
Song D, Yang JS, Kim SJ, Kim BK, Park SK, Won M, Lee K, Kim HM, Choi KY, Lee K, Han G.
Bioorgani and Medicinal Chemistry 2013 21:788-794 IF =2.921

Phospholipase D1 has a pivotal role in IL-1β-driven chronic autoimmune arthritis through regulation of NFκB, HIF-1α and FoxO3a.
Kang DW, Park MK, Oh, HJ, Lee DG, Park SH, Choi KY, Cho ML, Min DS.
MOLECULAR AND CELLULAR BIOLOGY 2013 32:2760-2772 IF =5.327

Isolation and maintenance of colorecal neural progenitor cells in vitro. (Book chapter)
Kim MY, Moon BS, Choi KY.
Springer 2013 1018:3-10

House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/AKT pathway.
Ro EJ, Cha PH, Kim HY, Cho YH, Park JW, Han JS, Choi KY.
Immunologic Research 2013 56:181-188 IF =3.026

Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells.
Cheol Son J, Woo Kang D, Mo Yang K, Choi KY, Gen Son T, Min DS.
Experimental and Molecular Medicine 2013 45:e38 IF =2.573

Stabilization of a-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition.
Kim B, Choi SJ, Han SH, Choi KY, Lim YB.
Chemical Communications 2013 49:7617-7619 IF =6.378

Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFkB transactivation.
Park MH, Kang DW, Jung Y, Choi KY, Min DS.
Biochem. Biophy. Res. Comm. 2013 6:1-2 IF =2.406

Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling.
Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, Lee TR.
Life Sciences 2012 91:19-20 IF =2.527

Rebamipide abolishes Helicobacter pylori CagA-induced phospholipase D1 expression via inhibition of NFkB and suppresses invasion of gastric cancer cells.
Kang DW, Hwang WC, Park MH, Ko GH, Ha WS, Kim KS, Lee YC, Choi KY, Min DS.
Oncogene 2012 72:1-12 IF =6.373

KR-POK interacts with p53 and represses CDKN1A transcription activation by p53.
Jeon BN, Kim MK, Choi WI, Koh DI, Hong SY, Kim KS, Kim M, Yun CO, Yoon J, Choi KY, Lee KR, Nephew KP, Hur MW.
Cancer Research 2012 72:1137-1148 IF =8.234

Co-treatment with retinyl retinoate and PPARα agonist reduces retinoid dermatitis.
Kim B, Kim JE, Kim H, Lee JD, Choi KY, Lee SH.
International Journal of Dermatology 2012 6:733-741 IF =1.265

Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility.
Lee SH, Zahoor M, Hwang JK, Min DS, Choi KY.
PLoS One 2012 7:e48791 IF =3.73

Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells.
Lee SH, Yoon J, Shin SH, Zahoor M, Kim HJ, Park PJ, Park WS, Min DS, Kim HY, Choi KY.
PLoS One 2012 7:e34152 IF =3.73

Perspective Reviewed
Ras Stabilization via Aberrant Activation of Wnt/b-catenin Signaling Promotes Intestinal Tumorigenesis.
Jeong WJ, Yoon J, Park JC, Lee SH, Lee SH, Kaduwal S, Kim H, Yoon JB, Choi KY.
Science signaling 2012 219:1-13 IF =7.499

Phospholipase D Meets Wnt Signaling: A New Target for Cancer Therapy.
Kang DW, Choi KY, Min DS.
Cancer Res. 2011 71:293-297 IF =8.234

N-Formyl-Methionyl-Leucyl-Phenylalanine (fMLP) Promotes Osteoblast Differentiation via the N-Formyl Peptide Receptor 1-mediated Signaling Pathway in Human Mesenchymal Stem Cells from Bone Marrow.
Shin MK, Jang YH, Yoo HJ, Kang DW, Park MH, Kim MK, Song JH, Kim SD, Min G, You HK, Choi KY, Bae YS, Min DS.
J Biol Chem. 2011 286:17133-17343 IF =5.328

A novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling.
Yao TW, Kim WS, Yu DM, Sharbeen G, McCaughan GW, Choi KY, Xia P, Gorrell M.
Molecular Cancer Research 2011 9:948-959 IF =4.373

Persicaria hydropiper (L.) Spach and its Flavonoid Components, Isoquercitrin and Isorhamnetin, Activate the Wnt/β-catenin Pathway and Inhibit Adipocyte Differentiation of 3T3-L1 Cells .
Lee SH, Kim B, Oh MJ, Yoon J, Kim HY, Lee KJ, Lee JD, Choi KY.
Phytotherapy research 2011 25:1629-1635 IF =1.878

N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high anti-oxidant activity and inhibits skin pigmentation.
Kim B, Kim JE, Lee SM, Lee SH, Lee JW, Kim MK, Lee KJ, Kim H, Lee JD, Choi KY.
Experimental Dermatology 2011 20:950-952 IF =4.159

Sur8/Shoc2 Involves Both Inhibition of Differentiation and Maintenance of Self-renewal of Neural Progenitor Cells via Modulation of ERK Signaling.
Moon BS, Kim HY, Kim MY, Yang DH, Lee JM, Cho KW, Jung HS, Choi KY.
Stem Cells 2011 29:320-331 IF =7.871

MEK1/2 Inhibitors, AS703026 and AZD6244, may be potential therapies for K-ras Mutated Colorectal Cancer that Is resistant to EGFR Monoclonal Antibody Therapy.
Yoon J, Koo KH, Choi KY.
Cancer Research 2011 71:445-453 IF =8.234

Retinyl retinoate induces hyaluronan production and less irritation than other retinoids.
Kim JE, Kim B, Kim H, Kim H, Lee JD, Kim HJ, Choi KY, Lee SH.
J Dermatol. 2010 37:1-7 IF =1.355

Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/ß-catenin/TCF signaling axis.
Kang DW, Lee SH, Yoon JW, Park WS, Choi KY, Min DS.
Cancer Research 2010 70:4233-4242 IF =8.234

BMP4 stimulates attachment of neurospheres and astrogenesis of neural stem cells in neurospheres via PI3 kinase-mediated upregulation of N-cadherin.
Kim MY, Kaduwal S, Yang DH, Choi KY.
Neuroscience 2010 170:8-15 IF =3.215

Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women.
Lee HJ, Koh JM, Hwang JY, Choi KY, Lee SH, Park EK, Kim TH, Han BG, Kim GS, Kim SY, Lee JY.
Calcif Tissue Int. 2009 84:439-445 IF =2.759

Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic β-cells.
Lee JW, Kim WH, Lim JH, Song EH, Song J, Choi KY, Jung MH.(Co-corresponding author)
Cellular signal. 2009 21:69-78 IF =4.243

Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis.
Kang SM, Kim SJ, Kim JH, Lee W, Kim GW, Lee KH, Choi KY, Oh JW.
Cancer Lett. 2009 279:230-237 IF =4.864

BMP4 stimulates neuronal differentiation of neuronal stem cells through ERK pathway.
Moon BS, Yoon JY, Kim MY, Lee SH, Choi T, Choi KY.
Exp Mol Med. 2009 41:116-125 IF =2.453

Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by P53 and Sp1.
Choi WI, Jeon BN, Yun CO, Kim PH, Kim SE, Choi KY, Kim SH, Hur MW.
J Biol Chem. 2009 284:12623-12633 IF =5.328

NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway.
Lee MY, Jeong WJ, Oh JW, Choi KY.
Cancer Lett. 2009 275:221-226 IF =4.864

Cover Paper, In this Issue Article
H-Ras is degraded by Wnt/b-catenin signaling via b-TrCP-mediated polyubiquitination.
Kim SE, Yoon JY, Jeong WJ, Jeon SH, Park Y, Yoon JB, Park YN, Kim H, Choi KY.
J Cell Sci. 2009 122:842-848 IF =6.290

Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/b-Catenin and Protein Kinase Ca.
Yang DH, Yoon JY, Lee SH, Bryja V, Andersson ER, Arenas E, Kwon YG, Choi KY.
Circ Res. 2009 100:327-349 IF =9.504

Nonstructural 5A protein activates β-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis.
Park CY, Choi SH, Kang SM, Kang JI, Ahn BY, Kim H, Jung G, Choi KY, Hwang SB.
J Hepatol. 2009 51:853-864 IF =9.334

Selected as a Highly Accessed Article
Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the β-catenin-Ras-ERK-p21Cip/WAF1 pathway.
Jung GA, Yoon JY, Moon BS, Yang DH, Kim HY, Lee SH, Bryja V, Arenas E, Choi KY.
BMC Cell Biol. 2008 9:66 IF =3.157

The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation.
Kim SE, Lee WJ, Choi KY.
Cellular Signal. 2007 19:511-518 IF =4.586

Axin is involved in the inhibition of cell proliferation by EGF.
Jeon SH, Jeong WJ, Cho JY, Lee KH, Choi KY.
Exp Mol Med. 2007 39:491-498 IF =2.376

Introduced as a Podcast Article in Homepage
Identification of proteins interacting with the catalytic subunit of PP2A by proteomics.
Lee WJ, Kim DU, Lee MY, Choi KY.
Proteomics 2007 7:206-214 IF =4.586

Selected as Top 20 Hottest Paper
EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation.
Kim SE, Choi KY.
Cellular Signal. 2007 19:1554-1564 IF =4.321

Cover Paper, Introduced as Science STKE Editor's Choice. (tw168, 2007)
Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via β-catenin.
Jeon SH, Yoon JY, Park YN, Jeong WJ, Kim S, Jho EH, Surh YJ, Choi KY.
J Biol Chem. 2007 282:14482-14492 IF =5.520

Chromosomal Information of 1,144 Korean BAC.
Han BG, Lee HJ, Kim KJ, Jeon JP, Lee HJ, Jeon JP, Kim JW, Kim HT, Cha HS, Kim CH, Choi KY, Park C, Oh B-S, Kim KC, Lee JY
Genomics Inform. 2006 4:141-146

Temporal cDNA microarray analysis of gene expression in human hepatocellular carcinoma upon radiation exposure.
Jeong J, Hong SJ, Ju YJ, Kim BY, Park MJ, Kim TH, Park CI, Choi KY, Cho MH, Kim SH, Lee H, Lee KH.
Oncol Rep. 2006 15:33-48 IF =1.524

β-catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances.
Kundu JK, Choi KY, Surh YJ.
Biochim Biophys Acta. - Reviews on Cancer 2006 1765:14-24 IF =10.238

Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53.
Ju YJ, Park JE, Juhn KM, Jeong J, Yun M, Park MJ,Choi KY, Choi MH, Wong KK, Lee KH.
Int J Oncol. 2006 29:753-763 IF =2.234

APC inhibits ERK pathway activation and cellular proliferation induced by Ras.
Park KS, Jeon SH, Kim SE, Bahk YY, Holmen SL, Williams BO, Chung KC, Surh YJ, Choi KY.
J Cell Sci. 2006 119:819-827 IF =6.247

Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the ERK pathway.
Lee JH, Lee JS, Kim SE, Moon BS, Kim YC, Lee SK, Lee SK, Choi KY.
Mol Cancer Ther. 2006 5:3222-3231 IF =5.003

Cover Story-Introduced as an in this issue article
Both ERK and the Wnt/β-catenin pathways are both involved in Wnt3a-induced proliferation.
Yun MS, Kim SE, Jeon SH, Lee JS, Choi KY.
J Cell Sci. 2005 118:313-322 IF =6.4

Transcriptional activity of Sp1 is regulated by molecular interaction between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.
Lee JA, Suh DC, Kang JE, Kim MH, Park H, Lee MN, Kim JM, Jeon BN, Roh HE, Yu MY, Choi KY, Kim KY, Hur MW.
J Biol Chem. 2005 280:28061-28071 IF =5.5

Regulation of Drosophila MKP-3 by Drosophila ERK.
Kim SE, Kim SH, Choi KY.
Ann N Y Acad Sci. 2004 1010:51-61

Activation of protein kinase C by 1-β-D-arabinofuranosylcytosine conjugates of phospholipid.
Lee KH, Jung YJ, Hong CI, Cho MH, Bai DH, Kim SH, Choi KY, Yu JH, Kim CM.
Int J Oncol. 2004 24:193-199

Control of transcriptional regulation in eukaryotes by a novel transcription factor derived from E. coli purine repressor.
Yeun EH, Noh J, Kim JM, Lee MY, Yoon S, Park SK, Choi KY, Kim KS.
Biochem Biophys Res Commun. 2004 319:334-341 IF =2.648

Identification of potential Corynebacterium ammoniagenes purine gene regulators using the pur-lacZ reporter in Escherica coli.
Han RN, Cho IH, Chung SO, Lee JK, Han JK, Choi KY.
J Microbiol Biotechnol. 2004 14:1249-1255

p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells.
Park KS, Jeon SH, Oh JW, Choi KY.
Exp Mol Med. 2004 36:557-566 IF =2.37

Feature gene of hepatitis B virus-positive hepatocellular carcinoma, established by its molecular discrimination approach using prediction analysis of microarray.
Kim BY, Lee JG, Park S, Ahn JY, Ju YJ, Chung JH, Han CJ, Jeong SH, Yeom YI, Kim S, Lee YS, Kim CM, Eom EM, Lee DH, Choi KY, Cho MH, Suh KS, Choi DW, Lee KH.
Biochim Biophys Acta. 2004 1739:50-61 IF =5

MKP-3 acts essential roles as a negative regulator of the Ras/MAPK pathway during Drosophila development.
Kim M, Cha GH, Kim S, Lee JH, Park J, Koh H, Choi KY, Chung J.
Mol Cell Biol. 2004 24:273-283 IF =5.942

Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells.
Kim SE, Cho JY, Kim KS, Lee SJ, Lee KH, Choi KY.
Cellular Signal. 2004 16:1309-1317 IF =4.6

The ERK pathway involves positive and negative regulations of HT29 colorectal cancer cell growth by extracellular zinc.
Park KS, Lee NG, Lee KH, Seo JT, Choi KY.
Am J Physiol Gastrointest Liver Physiol. 2003 285:1181-1188

The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma indomethacin-induced apoptosis of colon cancer cells.
Kim TI, Jin SH, Kang EH, Shin SK, Choi KY, Kim W.
Annals of the New York Academy of Sciences 2002 937:241-245

Regulation of the MAP kinase signaling pathway.
Kang-Yell Choi
Experimental and Molecular Medicine 2002 34:17-33

Differential modulation of zinc-stimulated p21Cip/WAF1 and cyclin D1 induction by inhibition of PI3 kinase in HT29 colorectal cancer cells.
Oh SY, Park KS, Kim JA, Choi KY.
Exp Mol Med. 2002 34:27-31

Isolation and characterization of a Drosophila homologue of MKP-3 which has a high substrate specificity toward ERK.
Kim SH, Kwon HB, Kim YS, Ryu JH, Kim KS, Ahn Y, Lee WJ, Choi KY.
Biochem J. 2002 361:143-151

Troglitazone Activates p21Cip/WAF1 through the ERK Pathway in HCT15 Human Colorectal Cancer Cells.
Kim JA, Park KS, Kim HI, Oh SY, Ahn Y, Oh JW, Choi KY.
Cancer Lett. 2002 179:185-195

Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells.
Kim HI, Cha JY, Kim SY, Kim JW, Roh KJ, Seong JK, Lee NT, Choi KY, Kim KS, Ahn YH.
Diabetes 2002 51:676-685

Drosophila extracellular signal regulated kinase involves in the insulin mediated proliferation of Schneider cells.
Kwon HB, Kim SH, Kim SE, Jang IH, Ahn Y, Lee WJ, Choi KY.
J Biol Chem. 2002 277:14853-14858

Extracellular zinc stimulates ERK-dependent activation of p21Cip/WAF1 and inhibits proliferation of colorectal cancer cells.
Park KS, Ahn Y, Kim JA, Yun MS, Seong BL, Choi KY.
Br J Pharmacol. 2002 137:597-607

The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma indomethacin-induced apoptosis of colon cancer cells.
Kim TI, Jin SH, Kang EH, Shin SK, Choi KY, Kim W.
Annals of the New York Academy of Sciences 2001 937:241-245

Saccharomyces cerevisiae Ste5 is important for induction and substrate specificity of Fus3 MAP kinase in the pheromone signaling pathway.
Choi YJ, Kim SK, Lee KS, Choi KY.
Molecules Cells 2000 10:301-308

Inhibition of MAPK by Drosophila MAPK phosphatase.
Lee WJ, Kim SH, Kim YS, Han SJ, Park KS, Ryu JH, Hur MW, Choi KY.
Biochemical Journal 2000 249:821-828

Prolonged activation of mitogen-activated protein kinases during NSAIDs-induced apoptosis in HT-29 colon cancer cells.
Kim TI, Jin SH, Kim WH, Kang EH, Choi KY, Kim HJ, Shin SK, Kang JK.
International Journal of Colorectal Diseases 2001 409:824-826